When we mentioned Dean’s speech to Sam in episode 10.03 to Ackles, he was quick to point out that it was Demon Dean saying these things.
"…someone asked me a minute ago, will these brothers ever give up on each other — they haven’t and they won’t.” Jensen Ackles
"… but at the end of the day, Sam will come through with Dean and get Dean back and it’ll be one of those things where we’re like ‘do we need to talk about it?’ ‘Not unless you want to.’ ‘Nope? Alright, let’s get a hamburger’.” Jensen Ackles
“There’s a quote, ‘You hurt most the ones you love’,” Padalecki said
"But at the end of the day, like everything, the show is about these two guys. They’re going to have to come back to together and work it out. It gets harder, it’s never easy, but somehow they end up doing it because at the end they love each other.” Adam Glass
When we asked Padalecki whether it’s time for Sam to finally be able to save Dean when he hasn’t been able to do so in the past (from Hell or Purgatory), Padalecki said “It is and it’s about damn time!”
And have no fear, Supernatural fans, because when asked if the Winchesters would learn to be brothers again and get back to the good side of the family business (you know, hunting people and saving things), Carver responded with a “yes!”